Virtual Data Rooms (VDRs) are safe and reliable methods to access confidential documents during business transactions. VDRs can be used to conduct due diligence during mergers and acquisitions and also help companies organize and share important documents with investors and other stakeholders. VDRs can also be used to organize and store invoices, contracts, and other documents for legal purposes, such as litigation or estate planning.
Members should be aware of the procedures and equipment installed on their vessels using a VDR/SVDR. It is also advisable to take the opportunity to think about upgrading and changing those that are inefficient or are not in compliance with minimum safety requirements.
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), binds to the vitamin D receptor (VDR) and retinoid X receptor (RXR) to form heterodimers that act on gene promoter regions known as vitamin D response elements. These genes regulate the expression of proteins involved in a myriad of physiological processes.
The VDR can be found in neurons, cells of glial origin, and subsets of them that are part the brain. In the primary hippocampal cells of rodents, VDR immunoreactivity was detected in oligodendrocytes. The VDR is also present in human neuroblastoma as well as astrocytes. The treatment of HL-60 leukemia cell lines by 1,25(OH2)2D3 resulted in monocyte-like differentiation and increased VDR levels. This effect was inhibited by inhibitors of the PI3K and MAPK pathways. In addition, VDR expression was increased in oligodendrocytes treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce megakaryoblastic leukemia cell maturation.